Since 1962, the Author and associates studid on the
rabbits brain systematically and demonstrated that the
3 areas in the cortex, 6 areas in the thalamus and hy-
pothalamus and 6 areas in the midbrain showed osmo-
receptic function by the osmotic stimulation, however
The urine amount of the rabbits stimulated with
hypertonic solution directly in these areas decreased
promptly and markedly. And these phenomenon might
be due to the release of ADH from the hypothalamus
and neurohypophysis.
However it is hardly to think that the prompt and
marked diuresis following the injection of H2O in the
above areas have resulted from the inhibition of, release
f ADH and or prompt depletion of ADH in the circu-
lation. Therefore I began to wonder ii some aaOuiti,
factor, possibly due to an unidentified hormone such as
diuretic hormone must be involved.
The present study was designed to examine the ques-
tion of whether or not there is a diuretic huinoraI
substance involved in the regulation of urine excretion,
Korean white male rabbits(Lepus cuudculus Linne´ Var.
domistics . Gmelin) weighing exactly 1. 8 kg were used
for this work.
They were well hydrated orally by 1gaveging with
100 cc of 2% sodium chloride solution three times at
one hour interval to maintain positive water balance
throught each study.
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